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Does naltrexone work for pain? Low dose naltrexone is a widely used but unproven "alternative" approach to chronic pain. At much lower doses of 4 - 4.5 mg daily, however, it has been shown in small, blinded, randomized trials to improve pain in fibromyalgia, gastrointestinal symptoms in Crohn's disease, and quality of life in multiple sclerosis. Can naltrexone cause depression? Because its affinity for mu receptors is greater than that of heroin and other opioid agonists, naltrexone is able to block the effects of other opioids. This may lead to extinguishing of drug-taking behaviour and may reduce opiate craving. Depression and dysphoria have been cited as adverse effects of naltrexone. Can you still get drunk on naltrexone? Naltrexone might block the pleasure effects of alcohol, but you can still get drunk while taking the medication.
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